Source: Orca session omp_c2f935d5_1054_44fe_92ad_6e1e97e62cb0, native session 01a155d1-0ef1-7259-b21a-7a511363dacc, October 19, 2026.
This is the original session write-up, preserved verbatim below. Desktop paths and verification claims refer to that original session, not this import. Full physician-level reference notes are preserved in notes.html and embedded below the figure in both rendered HTML pages.
Educational material only; not a clinical protocol. The original write-up distinguishes values attributed to the FDA label from unsourced teaching assumptions, including effect curves, tolerance, dopamine fold-change, and CYP2D6 inhibition. These medical and source claims have not been independently verified during import. Clinical review is required before teaching or patient-care use.
I built an interactive figure of the Adderall pathway, from capsule to blood, brain, synapse and urine. It's in ~/Desktop/02_projects/anatomy-adderall/: open adderall.html (dark) or adderall-light.html. Both pages build without errors and show no console errors in the browser, and the skill's line check passed on both.
What the figure shows, as one bench machine read left to right:
- Gut: two bead canisters. The right one has a 4 h timer for the delayed-release beads in XR, or for the second tablet in the twice-daily IR option.
- Plasma: a measuring column showing d-amphetamine under l-amphetamine, in ng/mL.
- Blood-brain barrier: a slotted plate the drug duct passes through.
- Dopamine nerve ending: four storage canisters (vesicles) on VMAT2 collars, a pool of free dopamine, and a TAAR1 lever. The highlighted rotor is the dopamine transporter: it runs forward for normal reuptake and backward when amphetamine makes it pump dopamine out.
- Synapse and effects: a tank whose level is synaptic dopamine relative to baseline, plus dials for prefrontal tone and heart rate.
- Elimination: a liver cartridge (CYP2D6) and a kidney block with a urine pH knob, each filling a beaker with the share of the dose cleared.
How to use it: hovering scrubs from 0 to 24 h after the dose. Buttons under the figure switch between XR 20 mg, IR 20 mg and IR 10 mg twice; urine pH 5.5, 6.5 or 8.0; and normal or strongly inhibited CYP2D6.
Below the figure are physician-level notes:
- mechanism by target (DAT/NET, VMAT2, TAAR1, SERT, MAO) and circuit effects (prefrontal D1/α2A, nucleus accumbens, periphery)
- labeled dosing
- the boxed warning, contraindications and safety monitoring
- drug interactions
- overdose management
- drug-test interpretation
How accurate the numbers are:
- From the FDA label: the drug levels. For XR 20 mg the model gives d-amphetamine 27 ng/mL at 7.1 h (label: 28.1, ~7 h), half-lives of 10 h for d and 13 h for l, and 35% excreted unchanged at usual urine pH (label: 30–40%).
- My teaching assumptions, not from a source: the effect curves, the tolerance rate, the dopamine fold-change scale and the 30% clearance drop with a CYP2D6 inhibitor.
- Tolerance: I added acute tolerance after the first version kept the effect high at 24 h. Effects now fade by about 10–12 h on XR while plasma levels are still a third of the peak.
The figure sizes the build as a "Hero" (about 120 parts). It hasn't been through the deeper geometry audit, because it has no pipes or turned parts. The files are build.mjs (rebuild with node build.mjs and node build.mjs --light), model.mjs, notes.html, the two HTML pages, and preview-dark.png / preview-light.png.